Study Finds Tau Protein Does Not Stabilize Microtubules, Challenges Approach to Treating Alzheimer's
![Human microtubule-associated-protein tau regulates the number of protofilaments in microtubules: a synchrotron x-ray scattering study. | Semantic Scholar Human microtubule-associated-protein tau regulates the number of protofilaments in microtubules: a synchrotron x-ray scattering study. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/6408a865176c20508332d85bfbdf339aaa9fbcaa/2-Figure1-1.png)
Human microtubule-associated-protein tau regulates the number of protofilaments in microtubules: a synchrotron x-ray scattering study. | Semantic Scholar
![Figure 2, [Microtubule-associated protein Tau (MAPT) aggregation...]. - Alzheimer's Disease: Drug Discovery - NCBI Bookshelf Figure 2, [Microtubule-associated protein Tau (MAPT) aggregation...]. - Alzheimer's Disease: Drug Discovery - NCBI Bookshelf](https://www.ncbi.nlm.nih.gov/books/NBK566126/bin/chapter1_f2.jpg)
Figure 2, [Microtubule-associated protein Tau (MAPT) aggregation...]. - Alzheimer's Disease: Drug Discovery - NCBI Bookshelf
![Frontiers | Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability Frontiers | Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability](https://www.frontiersin.org/files/MyHome%20Article%20Library/397506/397506_Thumb_400.jpg)
Frontiers | Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability
![Understanding Healthy Function of Tau, Protein Associated with Dementia | College of Biological Sciences Understanding Healthy Function of Tau, Protein Associated with Dementia | College of Biological Sciences](https://biology.ucdavis.edu/sites/g/files/dgvnsk13361/files/styles/sf_landscape_16x9/public/media/images/microtubule_0.png?h=c74750f6&itok=acEedrKX)
Understanding Healthy Function of Tau, Protein Associated with Dementia | College of Biological Sciences
![The microtubule-associated protein tau. The six human brain isoforms... | Download Scientific Diagram The microtubule-associated protein tau. The six human brain isoforms... | Download Scientific Diagram](https://www.researchgate.net/publication/229065778/figure/fig6/AS:669624567877650@1536662346641/The-microtubule-associated-protein-tau-The-six-human-brain-isoforms-of-tau-are.png)
The microtubule-associated protein tau. The six human brain isoforms... | Download Scientific Diagram
![Normal function of tau protein. Tau protein stabilizes microtubules... | Download Scientific Diagram Normal function of tau protein. Tau protein stabilizes microtubules... | Download Scientific Diagram](https://www.researchgate.net/publication/225294145/figure/fig2/AS:203155875864595@1425447543420/Normal-function-of-tau-protein-Tau-protein-stabilizes-microtubules-through-four-tubulin.png)
Normal function of tau protein. Tau protein stabilizes microtubules... | Download Scientific Diagram
![The microtubule-associated protein tau. The six human brain isoforms of... | Download Scientific Diagram The microtubule-associated protein tau. The six human brain isoforms of... | Download Scientific Diagram](https://www.researchgate.net/profile/Valerie-Vingtdeux/publication/229065778/figure/fig2/AS:203112011833345@1425437085061/The-microtubule-associated-protein-tau-The-six-human-brain-isoforms-of-tau-are_Q640.jpg)
The microtubule-associated protein tau. The six human brain isoforms of... | Download Scientific Diagram
![Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases | Nature Reviews Drug Discovery Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases | Nature Reviews Drug Discovery](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnrd2111/MediaObjects/41573_2007_Article_BFnrd2111_Fig1_HTML.jpg)
Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases | Nature Reviews Drug Discovery
![Alzheimer's disease–implicated protein tau puts the squeeze on microtubules | Nature Chemical Biology Alzheimer's disease–implicated protein tau puts the squeeze on microtubules | Nature Chemical Biology](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41589-022-01097-1/MediaObjects/41589_2022_1097_Fig1_HTML.png)
Alzheimer's disease–implicated protein tau puts the squeeze on microtubules | Nature Chemical Biology
![Oligomerization of the microtubule‐associated protein tau is mediated by its N‐terminal sequences: implications for normal and pathological tau action - Feinstein - 2016 - Journal of Neurochemistry - Wiley Online Library Oligomerization of the microtubule‐associated protein tau is mediated by its N‐terminal sequences: implications for normal and pathological tau action - Feinstein - 2016 - Journal of Neurochemistry - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/45216c46-831d-4371-bd8a-14e4393ba713/jnc13604-fig-0008-m.jpg)
Oligomerization of the microtubule‐associated protein tau is mediated by its N‐terminal sequences: implications for normal and pathological tau action - Feinstein - 2016 - Journal of Neurochemistry - Wiley Online Library
![The breakdown of clumped tau proteins to cure Alzheimer's disease | REVERSING TAUOPATHY Project | Results in brief | H2020 | CORDIS | European Commission The breakdown of clumped tau proteins to cure Alzheimer's disease | REVERSING TAUOPATHY Project | Results in brief | H2020 | CORDIS | European Commission](https://cordis.europa.eu/docs/results/images/2019-12/411682.jpg)
The breakdown of clumped tau proteins to cure Alzheimer's disease | REVERSING TAUOPATHY Project | Results in brief | H2020 | CORDIS | European Commission
![IJMS | Free Full-Text | Tau Protein Modifications and Interactions: Their Role in Function and Dysfunction IJMS | Free Full-Text | Tau Protein Modifications and Interactions: Their Role in Function and Dysfunction](https://www.mdpi.com/ijms/ijms-15-04671/article_deploy/html/images/ijms-15-04671f1-1024.png)